Daggannoth Supreme is part of the Combat Trio. Since he uses a ranged attackstyle, his weakness will be to melee attacks. Melee attacks are the only type of combat that can be used to kill the Daggannoth Supreme. It is recommended to use a Dharok's Set or a Lime Whip in order to destroy the giant beast. His ranged attack is very powerful, this being said you always have to use Protect From Missiles prayer in order to defeat him. Unlike real Runescape, there are no minions to worry about. Only the Daggannoth Kings are found in Waterbirth Island Dungeon.